Hyperuricemia is an increasingly prevalent metabolic disorder characterized by elevated serum uric acid levels exceeding 6.8 mg/dl and is a major risk factor for gout, renal disorders, and cardiovascular diseases. Although hyperuricemia is well defined in modern medicine as a disorder of purine metabolism or impaired renal excretion of uric acid, there is no direct disease entity described in Ayurveda corresponding to hyperuricemia. Hence, understanding this condition through Ayurvedic principles requires an analysis of Dosha, Dhatu, Srotas, and Agni involved in its pathogenesis. This conceptual review attempts to elucidate the applied physiology and etiopathogenesis of hyperuricemia in the light of classical Ayurvedic principles. A detailed review of Ayurvedic literature was undertaken to interpret hyperuricemia from the perspective of Panchamahabhuta predominance, Agni Vaigunya, and Dosha–Dushya Sammurchana. Parallels have been drawn between modern concepts of uric acid metabolism and Ayurvedic descriptions of Vidagdha Pitta, Rakta Dushti, and Vata Prakopa, particularly in relation to Purvarupa of Pittadhika Vatarakta. Hyperuricemia, especially in its asymptomatic stage, is proposed to represent an early stage of Samprapti rather than a distinct Vyadhi, functioning as a precursor for metabolic disorders such as gouty arthritis. The review aims to throw a light on ayurvedic understanding of hyperuricemia. Understanding hyperuricemia through this integrative approach may help in early diagnosis and formulation of preventive and therapeutic strategies based on Ayurvedic principles.
Hyperuricemia, Purvarupa of Pittadhika Vatarakta.
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